血栓形成傾向基因測試

【易被忽略的血栓】

血栓是血管中形成的血塊,當血塊愈來愈大,就會塞住血管,造成血栓塞症。

血栓形成易產生血栓體質的成因很多,其中基因變異是先天(遺傳)性易產生血栓體質的風險因素,有相關基因突變的人發生血栓風險將會增加80倍。

  • 全球每年有10, 000,000人因血栓形成而患上靜脈栓塞
  • 根據世界衛生組織 (WHO) 的統計資料顯示,血栓是造成心腦血管疾病的一大因素之一。因心腦血管疾病導致的死亡人數,比癌症的致死率還要來得高,可稱為人類健康的第一殺手。

【先天性血栓形成風險會導致什麼危險?】

  • 增加心腦血管病發送風險,如中風,冠心病,猝死。
  • 增加不良妊娠結果風險,如死胎、流產,胎兒生長受限、子癇前症、胎盤早剝
  • 增加慣性流產風險。

【誰應該進行此測試?】

  • 擔心發生血栓的人士
  • 吸煙
  • 肥胖
  • 40歲以上
  • 遺傳因素或患上心血管疾病的家族歷史

 

  如有以下情況,更應進行此測試:

【Pangenia 提供血栓形成傾向基因測試,預測血栓發生風險】

測試詳情

測試代碼
測試方法
樣本要求
測試所需時間
GTR
桑格 (Sanger) 基因測序
6ml EDTA 血液
5個工作天

 詳情請電郵至info@pangenialife.com 或致電 +852 3989 6160聯絡我們。

 

參考資料:

  1. White RH. The epidemiology of venous thromboembolism. Circulation. 2003;107(23 suppl 1):I4-I8.
  2. https://www.cdc.gov/ncbddd/dvt/data.html  US CDC, Data and Statistics on Venous Thromboembolism.
  3. Liew NC, Alemany GV, Angchaisuksiri P, Bang SM, Choi G, De Silva DA, et al. Asian venous thromboembolism guidelines: updated recommendations for the prevention of venous thromboembolism. Int Angiol 2017;36:1-20. DOI: 10.23736/S0392-9590.16.03765-2
  4. Lee LH, Gallus A, Jindal R, Wang C, Wu CC. Incidence of Venous Thromboembolism in Asian Populations: A Systematic Review. Thromb Haemost. 2017 Dec;117(12):2243-2260. doi: 10.1160/TH17-02-0134. Epub 2017 Dec 6. PMID: 29212112
  5. De Stefano V, Leone G (1995). "Resistance to activated protein C due to mutated factor V as a novel cause of inherited thrombophilia". Haematologica. 80(4): 344–56. PMID 7590506.
  6. Poort, Swibertus R, Rosendaal, Frits R, Reitsma, Pieter H, & Bertina, Rogier M. (1996). A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood, 88(10), 3698-3703.
  7. Frosst, Phyllis, Blom, Henk J, Milos, R, Goyette, Philippe, Sheppard, Christal A, Matthews, Rowena G, . . . Van Den Heuvel, LP. (1995). A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
  8. Den Heijer, M, Lewington, S, & Clarke, R. (2005). Homocysteine, MTHFR and risk of venous thrombosis: a meta‐analysis of published epidemiological studies. Journal of Thrombosis and Haemostasis, 3(2), 292-299.
  9. Andreassi, M. G., Botto, N., & Maffei, S. (2006). Factor V Leiden, prothrombin G20210A substitution and hormone therapy: indications for molecular screening. Clinical Chemical Laboratory Medicine, 44(5), 514-521.
  10. Wulf, G. M., Van Deerlin, V. M. D., Leonard, D. G. B., & Bauer, K. A. (1999). Thrombosis in a patient with combined homozygosity for the factor V Leiden mutation and a mutation in the 3'-untranslated region of the prothrombin gene. Blood coagulation & fibrinolysis, 10(2), 107-110.
  11. van der Put, N. M., Gabreëls, F., Stevens, E. M., Smeitink, J. A., Trijbels, F. J., Eskes, T. K., ... & Blom, H. J. (1998). A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?. The American Journal of Human Genetics, 62(5), 1044-1051
  12. Previtali, E., Bucciarelli, P., Passamonti, S. M., & Martinelli, I. (2011). Risk factors for venous and arterial thrombosis. Blood Transfus, 9(2), 120-138.
  13. Rabe, T., Luxembourg, B., Ludwig, M., Dinger, J. C., Bauersachs, R., Rott, H., ... & Albring, C. (2011). Contraception and Thrombophilia-A statement from the German Society of Gynecological Endocrinology and Reproductive Medicine (DGGEF e. V.) and the Professional Association of the German Gynaecologists (BVF e. V.). Journal für Reproduktionsmedizin und Endokrinologie-Journal of Reproductive Medicine and Endocrinology, 8(1), 178-218.

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