ROS1 gene fusion screening

What is ROS1 ?

ROS1 (ROS proto-oncogene 1) encodes for a protein which is known to induce cancerous activities in non-small cell lung cancer (NSCLC) 1-2. ROS1 is activated when fused with other genes, including SLC34A2, CD74, SDC4, EZR and so on.

Why is detecting ROS1 important?

It has been reported that the presence of ROS1 gene rearrangement is correlated with the efficacy of the related targeted therapy3. The detection of such gene fusions may provide rational therapeutic strategies for these patients.

What is this test for?

Pangenia ROS1 gene fusion screening Test uses real-time PCR to detect fourteen ROS1 gene fusions related to cancer that have been identified so far.

Who should consider this test?

Patients who are suffering from NSCLC and/or patients who have received targeted therapy and failed to show signs of recovery are advised to perform this test.

Test Specifications

Test Code
Methodology
Specimen Requirements
Turnaround Time
ORS
Real-time PCR (RT-PCR)
4 FFPE unstained sections (6μm) with at least 20% tumor content
5 days

What should I do if my test results are positive?

Please consult your physicians for professional advices.

How to get started

Our tests must be ordered by a doctor. Ask your doctor if a Mygenia test is right for you. We can help you find a doctor if you don’t have one.

I have a doctor
References
  1. Bergethon, Kristin, et al. "ROS1 rearrangements define a unique molecular class of lung cancers." Journal of clinical oncology 30.8 (2012): 863-870.
  2. Jänne, Pasi A., and Matthew Meyerson. "ROS1 rearrangements in lung cancer: a new genomic subset of lung adenocarcinoma." Journal of Clinical Oncology30.8 (2012): 878-879.
  3. Ou, Sai-Hong Ignatius, et al. "ROS1 as a 'druggable' receptor tyrosine kinase: lessons learned from inhibiting the ALK pathway." (2012): 447-456.