HPV DNA genotyping
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What is cervical cancer?

According to the worldwide statistics,

  • a woman dies of cervical cancer in every minutes
  • a woman is diagnosed with cervical cancer in every eight seconds

According to HKCaR’s statistics, cervical cancer is fourth most common cancer in women worldwide. From 2017, cervical cancer has caused over 2.6%+ of female cancer deaths. Studies states that over 90-91% cervical cancer are infected by HPV *. If we wish to prevent cervical cancer, we must understand the main cause and factors of cervical cancer.

More than 90-91% of cervical cancers are infected by HPV

The medical profession has confirmed that almost all cervical cancers (90-91%) are caused by persistent infection with Human Papillomavirus (HPV). Compared with low-risk HPV, persistent infection with high-risk HPV causes cervical cancers. The chance of causing cervical cancer is at least 30 times higher*. Therefore, we must first understand the cause of cancer before prevention of cervical cancer.

+ https://www3.ha.org.hk/cancereg/tc/topten.html
*  https://www.nccc-online.org/hpvcervical-cancer/cervical-cancer-overview/ 

What is HPV?

HPV is the most common sexually transmitted infection. HPV is a group of related viruses with more than 200 subtypes. There are around 40 subtypes that can infect the genitals of males and females. Some subtypes (e.g. HPV 16 and 18) cause cervical cancer and are referred to as high-risk subtypes. In contrast, low-risk subtypes are ones that cause genital warts (e.g. HPV 6 and 11).

How to detect cervical cancer?

Cervical cancer can be detected by the Pap test. It can find abnormal changes in cells lining the cervix. However, HPV infection can be latent for years before it progresses to abnormal changes of the cervix that can be detected by the Pap test. HPV DNA test can detect HPV infection and the associated subtype(s) at an earlier stage. Hence, early detection of high-risk HPV subtypes in conjunction with continuous monitoring of cervical cytology can effectively prevents the development of cancer.

What is this test for?

This test (test code: IHG) genotypes 33 HPV subtypes including 17 high-risk HPV genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68b, 73 and 82) and 16 low-risk HPV genotypes (6, 11, 26, 40, 42, 43, 44, 54, 55, 57, 61, 70, 71, 72, 81 and 84), which accounts for about 97.9% of HPV infections in the general population by analyzing viral DNA in specimen. It is done by GenoFlow HPV Array Test Kit. Combined tests with manual reviewed Pap Test (test code: IHM) or dual reviewed Pap Test (test code: IHD) are also available.

Who should consider the test?

  • Sexually active individual
  • Previous infection with high and/or low risk group of HPV subtype(s)
  • Having persistent HPV infection
  • Regular health checkup/screening 

Test Specifications

Test Code
Specimen Requirements
Turnaround Time
DNA Flow-through hybridization
Cervical brushing in 20 mL ThinPrep or 10 mL SurePath
3 days
DNA Flow-through hybridization and Pap test (Manual review)
Cervical brushing in 20 mL ThinPrep or 10 mL SurePath
5 days
DNA Flow-through hybridization and Pap test (Dual review)
Cervical brushing in 20 mL ThinPrep or 10 mL SurePath
5 days

Sample requirements and handling instruction


Samples should be collected using a cervical broom and placed in liquid-based cytology preservative.

Rejection criteria

  • Specimen without proper labeling
  • Specimen not in requested format or insufficient quantity
  • Specimen in expired container
  • Container leakage
  • Sampling date is more than 14 days
  • Test request form without / with mismatched patient identification information

Factor(s) known to affect results

  • Improper collection, handling and storage of specimen
  • Inadequate specimen

Storage instruction

Specimen should be kept at room temperature.


Our HPV DNA genotyping test reports are reviewed and signed by certified medical lab technologist and pathologist.

How to get started

Our tests must be ordered by a doctor. Ask your doctor if a Mygenia test is right for you. We can help you find a doctor if you don’t have one.

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