BRCA1 & 2 MLPA screening
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What are BRCA1 and BRCA2?

BRCA1 and BRCA2 are human genes that produce proteins to repair damaged DNA. They help keep breast, ovarian, and other types of cells from growing and dividing too rapidly or in an uncontrolled way.

How do BRCA1 & 2 mutations cause cancer?

If there is any inherited mutation from either of BRCA1 or BRCA2 genes, cells are more likely to divide and change rapidly, which can lead to developing cancer. Breast and ovarian cancers caused by gene mutations are called “hereditary breast and ovarian cancers”.

How could BRCA1 & 2 MLPA Screening test reduce the risk of developing cancer?

BRCA1 & 2 MLPA screening detects large gene mutations (eg. gene rearrangement and deletions). These big changes are difficult to detect with other techniques. Therefore, this test can assist physicians in selecting the most optimal solution for breast and ovarian cancer management as well as providing risk assessment for individuals.

Is the test right for me?

If you belong to any below group, it is suggested to do this test.

  • Families with breast and ovarian and or prostate cancer, breast cancer in the family at a young age (45 and below)
  • Triple negative type of breast cancer, bilateral breast cancer
  • Men with breast cancer in the family
  • Families with breast cancer and other cancers including stomach, colorectal, pancreatic cancer

Precautions before testing

  • No transfusion of blood 1 month before the test
  • No organ Transplantation

Test Specifications

Test Code
Methodology
Specimen Requirements
Turnaround Time
OBA
Multiplex ligation-dependent probe amplification (MLPA)
6 mL blood in EDTA tube
7 days

What should I do if my test results are positive?

If you you get a negative result, it does not mean you are not under the risk of cancer. Please consult your physicians or genetic counselor for professional advices before taking any actions.

Sharing the result with family members. If the person carriers BRCA mutation(s), her/his family member has 50% chance inherits the same mutation(s). Telling them might help them decide if they should get tested or adopt some of the approaches to try to lower their risk.

How to get started

Our tests must be ordered by a doctor. Ask your doctor if a Mygenia test is right for you. We can help you find a doctor if you don’t have one.

I have a doctor
References
  1. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427554.htm
  2. http://www.who.int/cancer/detection/breastcancer/en/
  3. Pagon, Roberta A., et al. "BRCA1 and BRCA2 Hereditary Breast and Ovarian Cancer." (2013).