What is BRAF?
BRAF is a gene that produces a protein which participates in the cell growth pathway. The V600E mutation is the most common BRAF gene mutation found in human cancers.
How does BRAF cause cancers?
The BRAF gene belongs to a class of genes known as oncogenes. When mutated, it causes cells to grow uncontrolledly, becoming cancerous. The BRAF V600E gene mutation has frequently been found in melanoma as well as other forms of cancers in the colon, rectum, ovary, and thyroid gland. Several other mutations in the BRAF gene have also been associated with cancer1. These mutations are also known to cause drug resistance to EGFR-targeted therapies, the most common targeted therapy approach nowadays to treat cancer.
Why is detecting BRAF important?
BRAF V600E mutations are associated with significantly poor prognosis and higher recurrent and disease in patients with skin cancer and colorectal cancer. The screening test has emerged as an important tool for diagnosis, prognosis, treatment, and predicting patient outcome in response to targeted therapy for multiple cancer types.
Who should consider this test?
Patients who are suffering from skin cancer, colorectal cancer and / or other cancer types; or patients who have received targeted therapy and failed to show signs of recovery are both advised to perform this test.
What should I do if my test results are positive?
Please consult your physicians for professional advices.