What is ALK?
Approximately 80% of lung cancers are non-small cell lung cancers (NSCLC) 1. The anaplastic lymphoma kinase (ALK) gene frequently involves in gene fusions that lead to lung cancer.
How does ALK cause cancer?
When ALK gene fuses with other genes, fusion genes will form. ALK fusion genes lead to expression of defective ALK proteins, which have been identified to play an essential role in the growth of some lung cancers (eg. NSCLC).
Why is detecting ALK important?
Inhibition of ALK may be an effective treatment approach for patients with ALK-positive tumors2, 3. Detecting ALK fusions or variants with ALK FISH test helps treating physician select more effective therapies for patients with NSCLC.
Who should consider this test?
Patients who are suffering from NSCLC and/or patients who have received targeted therapy and failed to show signs of recovery are advised to perform this test.
What should I do if my test results are positive?
Please consult your physicians for professional advices.