Mygenia BRCA1 and BRCA2 panel
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What is BRCA1 and BRCA2?

BRCA1 and BRCA2 are human genes that produce proteins to repair damage DNA. They help keep breast, ovaries, and other types of cells from growing and dividing too rapidly or in an uncontrolled way.

How do BRCA1 and BRCA2 mutations cause cancer?

If there is any inherited mutation from either of BRCA1 or BRCA2 genes, cells are more likely to divide and change rapidly, which can lead to developing cancer. Breast and ovarian cancers caused by gene mutations are called “hereditary breast and ovarian cancers."

How does Mygenia BRCA1 and BRCA2 Panel test help lower cancer risk?

Mygenia BRCA1 & BRCA2 panel is a genetic test which detects the mutations in BRCA1 and BRCA2 genes, by next-generation sequencing (NGS) technology. It maps the risk of getting hereditary cancer and allows people to start early prevention.

Is the test right for me?

If you belong to any below group, it is suggested to do this test.

  • Families with breast and ovarian and or prostate cancer, breast cancer in the family at a young age (45 and below)
  • Triple negative type of breast cancer, bilateral breast cancer
  • Men with breast cancer in the family
  • Families with breast cancer and other cancers including stomach, colorectal, pancreatic cancer

Precautions before testing

  • No transfusion of blood 1 month before the test
  • No organ transplantation

Test Specifications

Test Code
Methodology
Specimen Requirements
Turnaround Time
OB3
Next generation sequencing (NGS)
6 mL blood in EDTA tube
25 days
OB2
Next generation sequencing (NGS)
6 mL blood in EDTA tube
14 days
OB1
Next generation sequencing (NGS)
6 mL blood in EDTA tube
7 days

What should I do if my test results are positive?

If you you get a negative result, it does not mean you are not under the risk of cancer. Please consult your physicians or genetic counselor for professional advices before taking any actions.

Sharing the result with family members. If the person carriers BRCA mutation(s), her/his family member has 50% chance inherits the same mutation(s). Telling them might help them decide if they should get tested or adopt some of the approaches to try to lower their risk.

How to get started

Our tests must be ordered by a doctor. Ask your doctor if a Mygenia test is right for you. We can help you find a doctor if you don’t have one.

I have a doctor
References
  1. Easton DF. How many more breast cancer predisposition genes are there? Breast Cancer Research 1999; 1(1):14–17.
  2. Brose MS, Rebbeck TR, Calzone KA, et al. Cancer risk estimates for BRCA1 mutation carriers identified in a risk evaluation program. Journal of the National Cancer Institute 2002; 94(18):1365–1372.
  3. Levy-Lahad E, Friedman E. Cancer risks among BRCA1 and BRCA2 mutation carriers.British Journal of Cancer 2007; 96(1):11–15.
  4. Ferrone CR, Levine DA, Tang LH, et al. BRCA germline mutations in Jewish patients with pancreatic adenocarcinoma. Journal of Clinical Oncology 2009; 27(3):433–438.
  5. U.S. Preventive Services Task Force. Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer in Women: Clinical Summary of USPSTF Recommendation. AHRQ Publication No. 12-05164-EF-3. December 2013.
  6. Burke W, Daly M, Garber J, et al. Recommendations for follow-up care of individuals with an inherited predisposition to cancer. II. BRCA1 and BRCA2. Cancer Genetics Studies Consortium. JAMA 1997; 277(12):997–1003.
  7. King MC, Wieand S, Hale K, et al. Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP–P1) Breast Cancer Prevention Trial. JAMA 2001; 286(18):2251–2256.